Host Cell Invasion by Apicomplexan Parasites: The Junction Conundrum
نویسندگان
چکیده
1 Institut Pasteur, Malaria Biology and Genetics Unit, Department of Parasitology and Mycology, Paris, France, 2 Institut Cochin, Laboratory Barriers and Pathogens, INSERM U-1016, CNRS UMR-8104, University of Paris Descartes, Paris, France, 3 Institute of Infection, Immunity and Inflammation, Wellcome Centre for Molecular Parasitology, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, United Kingdom
منابع مشابه
Apical membrane antigen 1 mediates apicomplexan parasite attachment but is dispensable for host cell invasion
Apicomplexan parasites invade host cells by forming a ring-like junction with the cell surface and actively sliding through the junction inside an intracellular vacuole. Apical membrane antigen 1 is conserved in apicomplexans and a long-standing malaria vaccine candidate. It is considered to have multiple important roles during host cell penetration, primarily in structuring the junction by int...
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The apicomplexan moving junction (MJ) is a highly conserved structure formed during host cell entry that anchors the invading parasite to the host cell and serves as a molecular sieve of host membrane proteins that protects the parasitophorous vacuole from host lysosomal destruction. While recent work in Toxoplasma and Plasmodium has reinforced the composition of the MJ as an important associat...
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